How does the WHI study alter the risk–benefit ratio of HT?☆

Good clinical practice depends on knowledge of the current best medical care research evidence, but clinicians must be able to determine what is the best evidence and whether this evidence is relevant to their own patients. At the heart of evidence-based medicine is the assessment of the validity, importance, and relevance of a given study. These may be evaluated by asking key questions; here these questions are applied to the WHI study.